Course Details

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Course Information
SemesterCourse Unit CodeCourse Unit TitleT+P+LCreditNumber of ECTS CreditsLast Updated Date
1EE445FUNDAMENTALS OF BIOMEMS3+0+03514.05.2026

 
Course Details
Language of Instruction English
Level of Course Unit Bachelor's Degree
Department / Program ELECTRICAL-ELECTRONICS ENGINEERING
Type of Program Formal Education
Type of Course Unit Elective
Course Delivery Method Face To Face
Objectives of the Course (1) Introducing students to the fundamental principles of MEMS technology, microfabrication processes, and biocompatible materials used in BioMEMS device design and fabrication.
(2) Enabling students to analyze microfluidic principles and apply them to the design of lab-on-a-chip, biosensor, and point-of-care diagnostic systems.
(3) Developing students' ability to evaluate implantable MEMS devices, controlled drug delivery systems, and cell manipulation technologies in biomedical applications.
(4) Equipping students with an understanding of current challenges, bioethical considerations, regulatory pathways, and emerging trends in BioMEMS research and commercialization.
Course Content This course provides a comprehensive introduction to BioMEMS (Biological Micro-Electro-Mechanical Systems) and their applications in biomedical engineering. Topics include microfabrication techniques, biocompatible materials, microfluidics, lab-on-a-chip systems, biosensors, implantable MEMS devices, drug delivery systems, cell manipulation technologies, and BioMEMS applications in diagnostics, therapeutics, and tissue engineering. Laboratory sessions introduce students to cleanroom protocols, photolithography, and soft lithography techniques.
Course Methods and Techniques
Prerequisites and co-requisities None
Course Coordinator Associate Prof.Dr. Kutay İçöz
Name of Lecturers Research Assist.Dr. SİNAN GENÇ
Assistants Research Assist.Dr. Sinan Genç
Work Placement(s) No

Recommended or Required Reading
Resources Bhattacharya, S., Datta, A., Berg, J. M. & Bhattacharya, S. – BioMEMS and Biomedical Nanotechnology, Springer, 2006.
Madou, M. J. – Fundamentals of Microfabrication and Nanotechnology, 3rd Edition, CRC Press, 2011.
Saliterman, S. – Fundamentals of BioMEMS and Medical Microdevices, SPIE Press & Wiley, 2006.
Nguyen, N. T. & Wereley, S. T. – Fundamentals and Applications of Microfluidics, 2nd Edition, Artech House, 2006.
Thévenot, D. R. et al. – Electrochemical Biosensors: Recommended Definitions and Classification, Biosensors and Bioelectronics, 2001.


Planned Learning Activities and Teaching Methods
Activities are given in detail in the section of "Assessment Methods and Criteria" and "Workload Calculation"

Assessment Methods and Criteria
In-Term Studies Quantity Percentage
Quiz/Küçük Sınav 4 % 10
Ödev 6 % 20
Proje/Çizim 1 % 10
Final examination 1 % 35
Diğer (Staj vb.) 1 % 25
Total
13
% 100

 
ECTS Allocated Based on Student Workload
Veri yok

 
Course Learning Outcomes: Upon the successful completion of this course, students will be able to:
NoLearning Outcomes
1 Explain the fundamental principles of MEMS scaling laws, microfabrication processes (photolithography, wet/dry etching, thin film deposition, soft lithography), and cleanroom protocols used in BioMEMS device fabrication.
2 Identify and evaluate biocompatible materials (silicon, polymers, hydrogels, PDMS) and surface modification techniques used to achieve stable and selective biological interfaces in BioMEMS devices.
3 Analyze the principles of microfluidics and apply them to the design of lab-on-a-chip, point-of-care diagnostic systems, and biosensor platforms including electrochemical, optical, and mechanical transduction mechanisms.
4 Evaluate the design, fabrication, and performance of implantable MEMS devices, controlled drug delivery systems, and cell manipulation platforms including dielectrophoresis, optical tweezers, and microfluidic cell sorting.
5 Assess current challenges, bioethical considerations, regulatory pathways, and emerging research directions in BioMEMS including organ-on-a-chip, wearable biosensors, and personalized medicine applications.

 
Weekly Detailed Course Contents
WeekTopicsStudy MaterialsMaterials
1 BioMEMS'e giriş: tanım, tarihsel gelişim, uygulama alanları ve MEMS ölçekleme yasaları
2 Mikrofabrikasyon temelleri: fotolitografi, maske tasarımı ve temiz oda protokolleri
3 Aşındırma ve biriktirme teknikleri: ıslak/kuru aşındırma, PVD, CVD ve oksitasyon
4 Yumuşak litografi ve polimer tabanlı fabrikasyon: PDMS kalıplama ve mikrokontakt baskı
5 Biyouyumlu malzemeler ve yüzey fonksiyonelleştirme: silikon, polimerler, hidrojeller ve SAM'lar
6 Mikroakışkan temelleri: basınç güdümlü akış, elektroosmos, elektroforez ve mikropump tasarımı
7 Çip üzerinde laboratuvar (Lab-on-a-Chip) sistemleri ve hasta başı tanı (POC) uygulamaları
8 Ara Sınav
9 Biyosensörler I: elektrokimyasal ve optik biyosensörler — prensip, yapı ve uygulama
10 Biyosensörler II: mekanik ve piezoelektrik biyosensörler; QCM ve kantilever tabanlı sistemler
11 İmplante edilebilir MEMS cihazlar: nöral problar, basınç sensörleri ve koklear implantlar
12 Kontrollü ilaç salım sistemleri: mikrorezervuarlar, akıllı polimerler ve elektrokimyasal salım
13 Hücre manipülasyon teknolojileri: dielektroforez (DEP), optik penseler ve mikroakışkan hücre ayırma
14 Organ-on-a-chip, giyilebilir biyosensörler, biyoetik ve düzenleyici süreçler; final proje sunumları

 
Contribution of Learning Outcomes to Programme Outcomes
P1 P2 P3 P4 P5 P6 P7 P8 P9 P10 P11 P12
C1 5 3 4 2 2 2 2 4
C2 5 3 3 2 3 2 2 3
C3 4 5 4 2 4 2 3 2 3 4 2
C4 4 4 4 3 4 3 2 5 2 4 3 3
C5 3 3 2 3 2 5 3 4 3 4 2 3

  Contribution: 1: Very Slight 2:Slight 3:Moderate 4:Significant 5:Very Significant

  
  https://sis.agu.edu.tr/oibs/bologna/progCourseDetails.aspx?curCourse=79011&lang=en
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