Course Details

Course Information

Semester	Course Unit Code	Course Unit Title	T+P+L	Credit	Number of ECTS Credits	Last Updated Date
1	BENG617	GLYCO-PROTEIN ENGINEERING	3+0+0	3	7,5	14.05.2025

Course Details

Language of Instruction	English
Level of Course Unit	Doctorate's Degree
Department / Program	BIOENGINEERING
Type of Program	Formal Education
Type of Course Unit	Elective
Course Delivery Method	Face To Face
Objectives of the Course	To review the glycosylation machinery in vivo and vitro systems. To point out the importance of glycosylation for protein stability and function. To explain the importance of glycosylation for therapeutic and their improved properties and economical values.
Course Content	This class covers the recent developments and applications of protein glycosylation. The class starts with the importance of glycosylation for protein function and stability. This will be followed by reviewing the in vivo glycosylation machinery, in vitro glycosylation systems and their applications in therapeutics.
Course Methods and Techniques	This course is delivered through a research-oriented and student-centered instructional approach that combines advanced theoretical instruction with critical analysis of current literature. Interactive lectures are complemented by student-led seminars, journal club sessions, and case-based discussions focused on the functional and structural roles of protein glycosylation. Students engage in in-depth reviews of in vivo and in vitro glycosylation systems and their therapeutic applications through literature analysis and project-based learning. Emphasis is placed on developing skills in research design, hypothesis generation, scientific writing, and oral presentation. Individual and group assignments are incorporated to foster analytical thinking and collaborative problem-solving within the context of current developments in glycoscience.
Prerequisites and co-requisities	None
Course Coordinator	None
Name of Lecturers	Asist Prof.Dr. EMEL BAŞAK GENCER AKÇOK
Assistants	None
Work Placement(s)	No

Recommended or Required Reading

Resources

Essentials of Glycobiology (4th Edition) Editors: Ajit Varki, Richard D. Cummings, Jeffrey D. Esko, and others
Protein Glycosylation: Advances in Identification, Characterization and Biological Function Editor: Michelle Kilcoyne

Course Category

Science

%100

Planned Learning Activities and Teaching Methods

Activities are given in detail in the section of "Assessment Methods and Criteria" and "Workload Calculation"

Assessment Methods and Criteria

In-Term Studies	Quantity	Percentage
Yarıyıl İçi Çalışmalarının Başarı Notunun Katkısı	1	% 20
Ödev	5	% 20
Proje/Çizim	1	% 25
Final examination	1	% 35
Total	8	% 100

ECTS Allocated Based on Student Workload

Activities	Quantity	Duration	Total Work Load
Ev Ödevi	5	4	20
Sunum için Hazırlık	1	6	6
Sunum	1	2	2
Proje	1	20	20
Okuma	7	2	14
Araştırma	14	3	42
Kişisel Çalışma	14	3	42
Yüz Yüze Ders	14	3	42
Final Sınavı	1	20	20
Total Work Load			Number of ECTS Credits 7,5 208

Course Learning Outcomes: Upon the successful completion of this course, students will be able to:

No	Learning Outcomes
1	Express the importance of glycosylation.
2	Describe different types of glycosylation.
3	Define glycosylation pathways in vivo and in vitro
4	Design an in vivo and vitro systems to improve the protein properties such as activity and stability.

Weekly Detailed Course Contents

Week	Topics	Study Materials	Materials
1	Introduction to Protein Glycosylation
2	N-Linked Glycosylation Pathways
3	O-Linked Glycosylation and Mucin-type Glycans
4	Other Types of Glycosylation C-mannosylation, glypiation, phosphorylation of sugars
5	Glycan Function in Protein Folding and Stability
6	Analytical Methods for Glycan Characterization
7	In Vivo Glycosylation Engineering
8	In Vitro Glycosylation Systems
9	Therapeutic Glycoproteins
10	Glycosylation and Immune Modulation
11	Glycosylation in Cancer and Infectious Diseases
12	Glycoinformatics and Structural Databases
13	Future Directions in Glycoengineering AI in glycomics, programmable glycosylation, synthetic glycobiology
14	Application of glycol-engineering for therapeutics

Contribution of Learning Outcomes to Programme Outcomes

	P1	P2	P3	P4	P5	P6	P7	P8	P9	P10	P11	P12
C1	5	4	5	4	5	5	5	3	3	5	3	5
C2	5	4	5	4	5	5	5	3	3	5	3	5
C3	5	4	5	4	5	5	5	3	3	5	3	5
C4	5	4	5	4	5	5	5	3	3	5	3	5

Contribution: 1: Very Slight 2:Slight 3:Moderate 4:Significant 5:Very Significant

https://sis.agu.edu.tr/oibs/bologna/progCourseDetails.aspx?curCourse=78037&lang=en

Return to Classes