| Semester | Course Unit Code | Course Unit Title | T+P+L | Credit | Number of ECTS Credits | Last Updated Date |
| 5 | BENG436 | DRUG DESIGN & DISCOVERY | 3+0+0 | 3 | 5 | 14.05.2025 |
|
Language of Instruction
|
English
|
|
Level of Course Unit
|
Bachelor's Degree
|
|
Department / Program
|
BIOENGINEERING
|
|
Type of Program
|
Formal Education
|
|
Type of Course Unit
|
Elective
|
|
Course Delivery Method
|
Face To Face
|
|
Objectives of the Course
|
- Explaining the process of drug design and discovery from target identification to final
drug registration.
- Presenting target selection, lead discovery using computer-based methods and
combinatorial chemistry/high-throughput screening.
- Defining safety evaluation, bioavailability, clinical trials.
- Giving information about molecular recognition, computer-aided drug design, and
toxicology as applied to the development of new medicines
|
|
Course Content
|
This course covers the understanding of the history of drug design and discovery,
strategies of development of new drug candidates and the relationship between drug
discovery and chemical biology. Topics include enzyme inhibitors-related biostructure
and mechanism-based design and the structure, function and the pharmacology of
different receptors.
|
|
Course Methods and Techniques
|
|
|
Prerequisites and co-requisities
|
None
|
|
Course Coordinator
|
Asist Prof.Dr. İsmail AKÇOK ismail.akcok@agu.edu.tr
|
|
Name of Lecturers
|
Asist Prof.Dr. İSMAİL AKÇOK
|
|
Assistants
|
None
|
|
Work Placement(s)
|
No
|
Recommended or Required Reading
|
Resources
|
Textbook of Drug Design and Discovery, 5th edition by Kristian Strømgaard, Povl Krogsgaard-Larsen Ulf Madsen
|
Course Category
|
Mathematics and Basic Sciences
|
%30
|
|
|
Science
|
%30
|
|
|
Health
|
%40
|
|
|
Planned Learning Activities and Teaching Methods
Activities are given in detail in the section of "Assessment Methods and Criteria" and "Workload Calculation"
Assessment Methods and Criteria
|
In-Term Studies
|
|
Yarıyıl İçi Çalışmalarının Başarı Notunun Katkısı
|
1
|
%
30
|
|
Quiz/Küçük Sınav
|
2
|
%
30
|
|
Final examination
|
1
|
%
40
|
|
Total
|
4
|
%
100
|
ECTS Allocated Based on Student Workload
|
Activities
|
Total Work Load
|
|
Yazılı Sınav
|
1
|
10
|
10
|
|
Sunum
|
1
|
10
|
10
|
|
Kısa Sınav
|
2
|
5
|
10
|
|
Okuma
|
14
|
2
|
28
|
|
Yüz Yüze Ders
|
14
|
3
|
42
|
|
Final Sınavı
|
1
|
25
|
25
|
|
Total Work Load
| |
|
Number of ECTS Credits 5
125
|
Course Learning Outcomes: Upon the successful completion of this course, students will be able to:
| No | Learning Outcomes |
|
1
| To describe the process of drug design and discovery. |
|
2
| To discuss the challenges faced in each step of the drug discovery process. |
|
3
| To develop basic knowledge of computational methods used in drug discovery. |
|
4
| To determine the screening systems and classify the principles in pharmacokinetics and pharmacodynamics |
Weekly Detailed Course Contents
| Week | Topics | Study Materials | Materials |
| 1 |
Drug Discovery and Development: An Overview of Modern Methods of Principles
|
Reading
|
Textbook
|
| 2 |
Drug Discovery Process: From Ancient Times to the Present Day
|
Reading
|
Textbook
|
| 3 |
Drug Targets; Membrane Proteins, DNA, RNA, Enzymes
|
Okuma
|
Textbook
|
| 4 |
In vitro screening systems
|
Reading
|
Textbook
|
| 5 |
Structure Activity Relationships
|
Reading
|
Textbook
|
| 6 |
Molecular Modelling
|
Reading
|
Textbook
|
| 7 |
Ligand Based Drug Design
|
Reading
|
Textbook
|
| 8 |
Structure Based Drug Design
|
Reading
|
Textbook
|
| 9 |
Drug Delivery & Bioavailability
|
Reading
|
Textbook
|
| 10 |
Safety and Toxicology
|
Reading
|
Textbook
|
| 11 |
Pre-clinical Toxicology
|
Reading
|
Textbook
|
| 12 |
Clinical Trials – The Basics
|
Reading
|
Textbook
|
| 13 |
Translational Medicine and Biomarkers
|
Reading
|
Textbook
|
| 14 |
Case Studies in Drug Discovery
|
Reading
|
Textbook
|
Recommended Optional Programme Components
| BENG104 PRINCIPLES OF ORGANIC CHEMISTRY |
| BENG201 BIOCHEMISTRY |
Contribution of Learning Outcomes to Programme Outcomes
Contribution: 1: Very Slight 2:Slight 3:Moderate 4:Significant 5:Very Significant
https://sis.agu.edu.tr/oibs/bologna/progCourseDetails.aspx?curCourse=71974&lang=en