| Semester | Course Unit Code | Course Unit Title | T+P+L | Credit | Number of ECTS Credits |
| 1 | BENG624 | METASTASIS AND TUMOR MICROENVIRONMENT | 3+0+0 | 3 | 7,5 |
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Language of Instruction
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English
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Level of Course Unit
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Master's Degree
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Department / Program
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BIOENGINEERING
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Type of Program
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Formal Education
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Type of Course Unit
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Elective
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Course Delivery Method
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Face To Face
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Objectives of the Course
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Describing a general knowledge on molecular and cellular regulation of tumor cells and tumor cell-microenvironment interactions.
Identifying the roles of TME components during the process of cancer metastasis.
Arguing about the advantages and limitations of various approaches that are currently used in the cancer metastasis research.
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Course Content
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This course will introduce cancer, as a complex architecture comprised of different cell types and macromolecules that form intricate interactions for the good of the tumor “organ”. This course will discuss how tumor cells and other non-transformed specialized cells interact to constitute the “tumor microenvironment (TME)” and how this interaction facilitates the process of metastasis. In addition to that, the course will cover the multistage of metastasis that requires cancer cells to escape from the primary tumor, survive in the circulation, seed at distant sites, and grow.
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Course Methods and Techniques
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tudents-based active learning
Assignments as small-quizzes
Individual presentations
Midterm
Final exam
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Prerequisites and co-requisities
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None
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Course Coordinator
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None
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Name of Lecturers
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Associate Prof.Dr. AYSUN ADAN
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Assistants
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None
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Work Placement(s)
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No
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Recommended or Required Reading
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Resources
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Tumor Microenvironment by Peter P. Lee, Francesco M. Marincola, 2020
Scientific articles
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Canvas üzerinden ders notları belgesi ile paylaşılacaktır
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Canvas
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Canvas
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Yüz yüze sınıf ortamında
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Planned Learning Activities and Teaching Methods
Activities are given in detail in the section of "Assessment Methods and Criteria" and "Workload Calculation"
Assessment Methods and Criteria
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In-Term Studies
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Sunum/Seminer
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1
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%
40
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Final examination
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1
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%
60
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Total
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2
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%
100
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ECTS Allocated Based on Student Workload
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Activities
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Total Work Load
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Araştırma Ödevi
|
1
|
7
|
7
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Münazara
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14
|
1
|
14
|
|
Tartışma
|
14
|
1
|
14
|
|
Sınıf İçi Aktivitesi
|
6
|
2
|
12
|
|
Sunum için Hazırlık
|
1
|
6
|
6
|
|
Sunum
|
1
|
1
|
1
|
|
Araştırma
|
14
|
1
|
14
|
|
Kişisel Çalışma
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14
|
4
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56
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Takım/Grup Çalışması
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3
|
6
|
18
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Yüz Yüze Ders
|
14
|
3
|
42
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Derse Devam
|
10
|
3
|
30
|
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Final Sınavı
|
1
|
10
|
10
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Total Work Load
| |
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Number of ECTS Credits 7,5
224
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Course Learning Outcomes: Upon the successful completion of this course, students will be able to:
| No | Learning Outcomes |
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1
| Identify how TME components affect metastasis |
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2
| Design experiments to study TME in metastasis |
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3
| Compare therapeutic strategies to deal with TME effect on metastasis |
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4
| Assess the clinical impacts of TME on metastatic cancers |
Weekly Detailed Course Contents
| Week | Topics | Study Materials | Materials |
| 1 |
Overview for tumor metastasis
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| 2 |
EMT / Invasion / Intravasation/Extravasation and circulating tumor cells
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|
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| 4 |
Metastatic colonization at secondary tumor site
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| 7 |
Components of the TME
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| 8 |
Model systems and tools for TME research in the field of metastasis
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| 13 |
Pharmaceutical targeting of the TME
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Contribution of Learning Outcomes to Programme Outcomes
Contribution: 1: Very Slight 2:Slight 3:Moderate 4:Significant 5:Very Significant
https://sis.agu.edu.tr/oibs/bologna/progCourseDetails.aspx?curCourse=78044&lang=en