Course Details

GLYCO-PROTEIN ENGINEERING

BENG617

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Course Information
SemesterCourse Unit CodeCourse Unit TitleT+P+LCreditNumber of ECTS Credits
1BENG617GLYCO-PROTEIN ENGINEERING3+0+037,5

Course Details
Language of Instruction English
Level of Course Unit Master's Degree
Department / Program BIOENGINEERING
Type of Program Formal Education
Type of Course Unit Elective
Course Delivery Method Face To Face
Objectives of the Course To review the glycosylation machinery in vivo and vitro systems.
To point out the importance of glycosylation for protein stability and function.
To explain the importance of glycosylation for therapeutic and their improved properties and economical values.
Course Content This class covers the recent developments and applications of protein glycosylation. The class starts with the importance of glycosylation for protein function and stability. This will be followed by reviewing the in vivo glycosylation machinery, in vitro glycosylation systems and their applications in therapeutics.
Course Methods and Techniques This course is delivered through a research-oriented and student-centered instructional approach that combines advanced theoretical instruction with critical analysis of current literature. Interactive lectures are complemented by student-led seminars, journal club sessions, and case-based discussions focused on the functional and structural roles of protein glycosylation. Students engage in in-depth reviews of in vivo and in vitro glycosylation systems and their therapeutic applications through literature analysis and project-based learning. Emphasis is placed on developing skills in research design, hypothesis generation, scientific writing, and oral presentation. Individual and group assignments are incorporated to foster analytical thinking and collaborative problem-solving within the context of current developments in glycoscience.
Prerequisites and co-requisities None
Course Coordinator None
Name of Lecturers Asist Prof.Dr. EMEL BAŞAK GENCER AKÇOK
Assistants None
Work Placement(s) No

Recommended or Required Reading
Resources Essentials of Glycobiology (4th Edition) Editors: Ajit Varki, Richard D. Cummings, Jeffrey D. Esko, and others
Protein Glycosylation: Advances in Identification, Characterization and Biological Function Editor: Michelle Kilcoyne

Course Category
Science %100

Planned Learning Activities and Teaching Methods
Activities are given in detail in the section of "Assessment Methods and Criteria" and "Workload Calculation"

Assessment Methods and Criteria
In-Term Studies Quantity Percentage
Yarıyıl İçi Çalışmalarının Başarı Notunun Katkısı 1 % 20
Ödev 5 % 20
Proje/Çizim 1 % 25
Final examination 1 % 35
Total
8
% 100

 
ECTS Allocated Based on Student Workload
Activities Quantity Duration Total Work Load
Ev Ödevi 5 4 20
Sunum için Hazırlık 1 6 6
Sunum 1 2 2
Proje 1 20 20
Okuma 7 2 14
Araştırma 14 3 42
Kişisel Çalışma 14 3 42
Yüz Yüze Ders 14 3 42
Final Sınavı 1 20 20
Total Work Load   Number of ECTS Credits 7,5 208

Course Learning Outcomes: Upon the successful completion of this course, students will be able to:
NoLearning Outcomes
1 Express the importance of glycosylation.
2 Describe different types of glycosylation.
3 Define glycosylation pathways in vivo and in vitro
4 Design an in vivo and vitro systems to improve the protein properties such as activity and stability.


Weekly Detailed Course Contents
WeekTopicsStudy MaterialsMaterials
1 Introduction to Protein Glycosylation
2 N-Linked Glycosylation Pathways
3 O-Linked Glycosylation and Mucin-type Glycans
4 Other Types of Glycosylation C-mannosylation, glypiation, phosphorylation of sugars
5 Glycan Function in Protein Folding and Stability
6 Analytical Methods for Glycan Characterization
7 In Vivo Glycosylation Engineering
8 In Vitro Glycosylation Systems
9 Therapeutic Glycoproteins
10 Glycosylation and Immune Modulation
11 Glycosylation in Cancer and Infectious Diseases
12 Glycoinformatics and Structural Databases
13 Future Directions in Glycoengineering AI in glycomics, programmable glycosylation, synthetic glycobiology
14 Application of glycol-engineering for therapeutics


Contribution of Learning Outcomes to Programme Outcomes
P1 P2 P3 P4 P5 P6 P7 P8 P9 P10 P11 P12
C1 5 4 5 4 5 5 5 3 3 5 3 5
C2 5 4 5 4 5 5 5 3 3 5 3 5
C3 5 4 5 4 5 5 5 3 3 5 3 5
C4 5 4 5 4 5 5 5 3 3 5 3 5

Contribution: 1: Very Slight 2:Slight 3:Moderate 4:Significant 5:Very Significant


https://sis.agu.edu.tr/oibs/bologna/progCourseDetails.aspx?curCourse=78037&lang=en
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