Course Details

HUMAN DRUG METABOLISM

BENG626

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Course Information
SemesterCourse Unit CodeCourse Unit TitleT+P+LCreditNumber of ECTS Credits
4BENG626HUMAN DRUG METABOLISM3+0+037,5

Course Details
Language of Instruction English
Level of Course Unit Master's Degree
Department / Program BIOENGINEERING
Type of Program Formal Education
Type of Course Unit Elective
Course Delivery Method Face To Face
Objectives of the Course Defining the drug metabolism and action in human.
Realizing why drug causes adverse effects on human.
Comprehending the importance of drug metabolism in drug development.
Course Content Drug metabolism is how organisms break down drugs. The course begins with basic concepts such as clearance, bioavailability and biotransformation. Information on how cytochrome P450s function and how they are modulated at the sub-cellular level are examined in detail. Recent advances in phase II metabolizing systems are covered, including glucuronidation and sulphation, along with the leading drug transporters. Progress of personalized medicine from concepts towards practical is included. The final focus on how and why drugs injure us, both in predictable and unpredictable ways.
Course Methods and Techniques The course on Drug Metabolism employs a combination of interactive lectures, case-based learning, and student-led seminars to ensure deep understanding of drug clearance, bioavailability, and biotransformation. Lectures are used to establish foundational knowledge, while group discussions and real-world case studies foster critical thinking about cytochrome P450 function and modulation at the sub-cellular level. Practical workshops focus on interpreting current research on phase II metabolism (e.g., glucuronidation and sulphation) and drug transporters. Students engage in literature reviews and oral presentations to explore the evolution of personalized medicine and drug toxicity. Emphasis is placed on evidence-based learning, with continuous feedback and opportunities for peer and instructor interaction to refine analytical and communication skills.
Prerequisites and co-requisities None
Course Coordinator None
Name of Lecturers Asist Prof.Dr. EMEL BAŞAK GENCER AKÇOK
Assistants None
Work Placement(s) No

Recommended or Required Reading
Resources 1. "Drug Metabolism: Chemical and Enzymatic Aspects" Authors: Jack P. Uetrecht & William Trager
2. "Principles of Drug Metabolism" (Volume 1 & 2) Editors: Bernard Testa & Peter Jenner
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Course Category
Science %100

Planned Learning Activities and Teaching Methods
Activities are given in detail in the section of "Assessment Methods and Criteria" and "Workload Calculation"

Assessment Methods and Criteria
In-Term Studies Quantity Percentage
Yarıyıl İçi Çalışmalarının Başarı Notunun Katkısı 1 % 25
Ödev 5 % 20
Proje/Çizim 1 % 20
Final examination 1 % 35
Total
8
% 100

 
ECTS Allocated Based on Student Workload
Activities Quantity Duration Total Work Load
Ev Ödevi 5 4 20
Sunum için Hazırlık 1 6 6
Sunum 1 2 2
Proje 1 15 15
Araştırma 14 2 28
Kişisel Çalışma 14 3 42
Ders dışı çalışma 14 2 28
Yüz Yüze Ders 14 3 42
Final Sınavı 1 15 15
Total Work Load   Number of ECTS Credits 7,5 198

Course Learning Outcomes: Upon the successful completion of this course, students will be able to:
NoLearning Outcomes
1 Recognize the identity, distribution, regulation of major drug metabolizing enzymes.
2 Describe the advances in the scientific field of drug metabolism and its clinical impact.
3 Explain scientific and regulatory expectations concerning drug metabolism and transport studies and the impact in accelerating drug development.
4 Analyze the relationship between drug metabolism and personalized medicine.
5 List recent developments in drug discovery, genomics, and stem cell technologies.


Weekly Detailed Course Contents
WeekTopicsStudy MaterialsMaterials
1 Introduction to Drug Metabolism
2 Clearance and Bioavailability
3 Enzymes in Drug Metabolism – General Principles
4 Cytochrome P450 Enzyme System – Structure and Function
5 Regulation and Modulation of CYP450s
6 Phase II Metabolism – Glucuronidation
7 Phase II Metabolism – Sulfation, Acetylation, Methylation
8 Other Phase II Reactions and Novel Pathways
9 Transporters in Drug Disposition
10 Drug-Drug Interactions and Enzyme Inhibition
11 Pharmacogenetics and Personalized Medicine
12 Drug Metabolism and Toxicity – Mechanisms
13 Experimental Approaches to Study Drug Metabolism
14 Current Trends and Case Studies in Drug Metabolism


Contribution of Learning Outcomes to Programme Outcomes
P1 P2 P3 P4 P5 P6 P7 P8 P9 P10 P11 P12
C1 5 5 3 5 1 4 4 1 5 5
C2 5 5 3 5 1 4 4 1 5 5
C3 5 5 3 5 1 4 4 1 5 5
C4 5 5 3 5 1 4 4 1 5 5
C5 5 5 3 5 1 4 4 1 5 5

Contribution: 1: Very Slight 2:Slight 3:Moderate 4:Significant 5:Very Significant


https://sis.agu.edu.tr/oibs/bologna/progCourseDetails.aspx?curCourse=78007&lang=en
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