| Semester | Course Unit Code | Course Unit Title | T+P+L | Credit | Number of ECTS Credits |
| 1 | BENG623 | TRANSGENIC MICE | 3+0+0 | 3 | 7,5 |
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Language of Instruction
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English
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Level of Course Unit
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Master's Degree
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Department / Program
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BIOENGINEERING
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Type of Program
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Formal Education
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Type of Course Unit
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Elective
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Course Delivery Method
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Face To Face
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Objectives of the Course
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Defining embryonic stem cells and embryo transfer.
Recognising the gene replacement techniques.
Explaining the theory behind the production and process of transgenic mice.
Obtaining an insight into the use of transgenic mice in basic and translational research.
Modifying the best mouse models available for studying a variety of human pathologies.
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Course Content
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Transgenic mice are a valuable tool for studying a variety of human pathologies. This course includes a theoretical overview of the production of transgenic mice. Also, different gene modification techniques and generation of transgenic mouse models will be discussed throughout the course. The course aims at design and choose the best transgenic mouse model that best serves their object.
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Course Methods and Techniques
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The course will be conducted through lectures supported by visual materials and current literature reviews. Students will reinforce their knowledge through case studies and problem-based learning approaches. Additionally, they will gain practical skills in the design and evaluation of transgenic mouse models through group discussions and project-based applications.
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Prerequisites and co-requisities
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None
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Course Coordinator
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None
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Name of Lecturers
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Asist Prof.Dr. Sibel SARI TÜRK
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Assistants
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None
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Work Placement(s)
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No
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Recommended or Required Reading
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Resources
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Research Articles and reviews
Marten H. Hofker, Jan van Deursen transgenic Mouse: Methods and Protocols" (Methods in Molecular Biology series). Marten H. Hofker, Jan van Deursen
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transgenic Mouse: Methods and Protocols" (Methods in Molecular Biology series). Marten H. Hofker, Jan van Deursen
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canvas
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canvas
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canvas
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Course Category
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Science
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%50
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Health
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%40
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Field
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%10
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Planned Learning Activities and Teaching Methods
Activities are given in detail in the section of "Assessment Methods and Criteria" and "Workload Calculation"
Assessment Methods and Criteria
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In-Term Studies
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Sunum/Seminer
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10
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%
40
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Final examination
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1
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%
60
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Total
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11
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%
100
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ECTS Allocated Based on Student Workload
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Activities
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Total Work Load
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Tartışma
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14
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3
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42
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Sunum
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10
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3
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30
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Okuma
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14
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5
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70
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Araştırma
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10
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1
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10
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Ders dışı çalışma
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14
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2
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28
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Yüz Yüze Ders
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14
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3
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42
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Final Sınavı
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1
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3
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3
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Total Work Load
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Number of ECTS Credits 7,5
225
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Course Learning Outcomes: Upon the successful completion of this course, students will be able to:
| No | Learning Outcomes |
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1
| Define the theory behind the production of transgenic mice. |
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2
| Explain how genetic changes occur in the production process of the desired mouse model and which techniques need to be used. |
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3
| Examine the modeling of human diseases in mice and get an insight into select the suitable transgenic mouse model for the certain disease. |
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4
| Distinguish the importance and limitations of transgenic mice in translational research. |
Weekly Detailed Course Contents
| Week | Topics | Study Materials | Materials |
| 1 |
Introduction to the concept of transgenic animals and different genetic modification methods.
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| 2 |
The use of Transgenic Mice
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| 3 |
Homologous Recombination and Cre/Lox system
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| 4 |
CRISPR/Cas9 gene editing technology in mice
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| 5 |
Mouse Models for Human Diseases
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| 6 |
Humanized Mouse Models and Alternative methods
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| 7 |
Ethical Approaches to the Use of Transgenic Mice
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Contribution of Learning Outcomes to Programme Outcomes
Contribution: 1: Very Slight 2:Slight 3:Moderate 4:Significant 5:Very Significant
https://sis.agu.edu.tr/oibs/bologna/progCourseDetails.aspx?curCourse=78005&lang=en