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Language of Instruction
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English
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Level of Course Unit
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Master's Degree
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Department / Program
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BIOENGINEERING
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Type of Program
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Formal Education
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Type of Course Unit
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Elective
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Course Delivery Method
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Face To Face
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Objectives of the Course
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Providing advanced students of biology, biochemistry and chemistry, as well as with an overview of cell signaling and an orientation within this highly complicated area.
Identifying post-translational modi?cation, interaction partners and macromolecular associations of signaling proteins.
Addressing the extensive interplay and networking of signaling pathways and their component.
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Course Content
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The course will provide a detailed knowledge of molecular mechanisms of cell signaling with emphasis on the significance of signal transduction in physiology (such as apoptosis, cell cycle regulation, gene transcription) and pathophysiology (such as cancer and cardiovascular disease). The main signaling pathways and their functional properties, including different types of receptors and their signaling pathways, G proteins, protein kinases will be discussed together with their model systems and regulation. Accordingly, therapeutic strategies designed to specifically target altered signaling pathways in diseases will be discussed.
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Course Methods and Techniques
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Basic concepts and theoretical information are directly transferred by the instructor.
Advantage: A lot of information is transferred in a short time.
Questions and answers are used to increase the active participation of students in the course.
It is applied at the end of the subject or during the course to gather the attention of the students and reinforce the information.
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Prerequisites and co-requisities
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None
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Course Coordinator
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None
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Name of Lecturers
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Instructor Dr. Demet Şaylan
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Assistants
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None
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Work Placement(s)
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No
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Recommended or Required Reading
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Resources
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Biochemistry of Signal Transduction and Regulation. 2014. Wiley-VCH. Gerhard Krauss.
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This course focuses on cellular communication processes that begin with the activation of cell surface receptors and extend to the regulation of intracellular signaling pathways. Students will learn how the activation of signaling molecules resulting from ligand-receptor interactions, the production of secondary messengers, and ionic currents affect cellular functions. In addition, how these signaling pathways play a role in physiological processes and disease pathogenesis will be examined through sample pathways. The course aims to understand the effects of signaling networks on cell fate, proliferation, differentiation, and death at the molecular level.
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Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Lewis Cantley, Tony Thunter, Richard Sever and Jeremy Thorner.
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canvas
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Course Category
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Mathematics and Basic Sciences
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Engineering
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Engineering Design
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Social Sciences
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%0
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Education
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%0
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Science
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%100
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Health
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%0
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Field
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%0
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