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Language of Instruction
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English
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Level of Course Unit
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Bachelor's Degree
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Department / Program
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MOLECULAR BIOLOGY AND GENETICS
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Type of Program
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Formal Education
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Type of Course Unit
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Elective
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Course Delivery Method
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Face To Face
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Objectives of the Course
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This course will introduce new interdisciplinary area of study named “molecular medicine” that explores revolutionary developments in disease diagnosis, therapy and prevention, which is allowed by bio-molecular research.
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Course Content
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It shows how basic science is translated from ‘theory to the clinic.’ It covers advances in the personalised medicine that allowed the understanding of the disease mechanisms at cellular level, opening up new ways to treat major illnesses. The course’s main focus includes cancer, genetics, novel drugs (mechanisms).
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Course Methods and Techniques
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Lectures, particular talks by prominent scientists, quizzes, patient cases, articles will be included within the course content. Additionally, each student (as an individual or within groups ) is responsible from presenting an article in front of the class.
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Prerequisites and co-requisities
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None
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Course Coordinator
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None
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Name of Lecturers
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Asist Prof.Dr. Nurettin AYVALI nurettin.ayvali@agu.edu.tr
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Assistants
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None
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Work Placement(s)
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No
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Recommended or Required Reading
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Resources
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Lectures and some of the notes (on papers) would be shared. Some of the highlights regarding course content was indicated below.
Some of the highlights of the subjects included ...
Infant/62 year old died/affected due to undiagnosed pharmacogenetic marker
Keytruda: It was the first time that FDA approved a drug not based on cancer origin/site, but on biomarkers & (immunotherapy)
Patisiran: It was the first time that FDA approved a drug which shows RNA-interference (RNAi) pathway is druggable
Casgevy: It was the first time that FDA approved a CRISPR based therapy (sickle cell & thalessemia)
Use of induced Pluripotent Stem Cells and proof of concept example for gene therapy for disease treatment (sickle cell disease in a mouse model)
Economic Burden of Cancer (potential productive life lost...)
Hallmarks and Enabling Characteristics (Weinberg & Hanahan)
Tumor micro environment, TME (accessories to the crime)
Dysregulated apoptotic components/mechanisms in cancer
Nonmutational epigenetic reprogramming plays role in the carcinogenesis.
CRISPR loss-of-function libraries are being used to understand mechanisms of 'drug metabolism and/or resistance' (Cytarabine & Venetoclax (BCL2-inhibitor)).
Ethical Considerations & "Article" Reading, Analysis, Interpreting, Impacts and Limitations, Presenting ...
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Canvas
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Canvas announcement
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