Course Details

DRUG DESIGN & DISCOVERY

BENG436

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Course Information
SemesterCourse Unit CodeCourse Unit TitleT+P+LCreditNumber of ECTS Credits
5BENG436DRUG DESIGN & DISCOVERY3+0+035

Course Details
Language of Instruction English
Level of Course Unit Bachelor's Degree
Department / Program BIOENGINEERING
Type of Program Formal Education
Type of Course Unit Elective
Course Delivery Method Face To Face
Objectives of the Course - Explaining the process of drug design and discovery from target identification to final
drug registration.
- Presenting target selection, lead discovery using computer-based methods and
combinatorial chemistry/high-throughput screening.
- Defining safety evaluation, bioavailability, clinical trials.
- Giving information about molecular recognition, computer-aided drug design, and
toxicology as applied to the development of new medicines
Course Content This course covers the understanding of the history of drug design and discovery,
strategies of development of new drug candidates and the relationship between drug
discovery and chemical biology. Topics include enzyme inhibitors-related biostructure
and mechanism-based design and the structure, function and the pharmacology of
different receptors.
Course Methods and Techniques
Prerequisites and co-requisities None
Course Coordinator Asist Prof.Dr. İsmail AKÇOK ismail.akcok@agu.edu.tr
Name of Lecturers Asist Prof.Dr. İSMAİL AKÇOK
Assistants None
Work Placement(s) No

Recommended or Required Reading
Resources Textbook of Drug Design and Discovery, 5th edition by Kristian Strømgaard, Povl Krogsgaard-Larsen Ulf Madsen

Course Category
Mathematics and Basic Sciences %30
Science %30
Health %40

Planned Learning Activities and Teaching Methods
Activities are given in detail in the section of "Assessment Methods and Criteria" and "Workload Calculation"

Assessment Methods and Criteria
In-Term Studies Quantity Percentage
Yarıyıl İçi Çalışmalarının Başarı Notunun Katkısı 1 % 30
Quiz/Küçük Sınav 2 % 30
Final examination 1 % 40
Total
4
% 100

 
ECTS Allocated Based on Student Workload
Activities Quantity Duration Total Work Load
Yazılı Sınav 1 10 10
Sunum 1 10 10
Kısa Sınav 2 5 10
Okuma 14 2 28
Yüz Yüze Ders 14 3 42
Final Sınavı 1 25 25
Total Work Load   Number of ECTS Credits 5 125

Course Learning Outcomes: Upon the successful completion of this course, students will be able to:
NoLearning Outcomes
1 To describe the process of drug design and discovery.
2 To discuss the challenges faced in each step of the drug discovery process.
3 To develop basic knowledge of computational methods used in drug discovery.
4 To determine the screening systems and classify the principles in pharmacokinetics and pharmacodynamics


Weekly Detailed Course Contents
WeekTopicsStudy MaterialsMaterials
1 Drug Discovery and Development: An Overview of Modern Methods of Principles Reading Textbook
2 Drug Discovery Process: From Ancient Times to the Present Day Reading Textbook
3 Drug Targets; Membrane Proteins, DNA, RNA, Enzymes Okuma Textbook
4 In vitro screening systems Reading Textbook
5 Structure Activity Relationships Reading Textbook
6 Molecular Modelling Reading Textbook
7 Ligand Based Drug Design Reading Textbook
8 Structure Based Drug Design Reading Textbook
9 Drug Delivery & Bioavailability Reading Textbook
10 Safety and Toxicology Reading Textbook
11 Pre-clinical Toxicology Reading Textbook
12 Clinical Trials – The Basics Reading Textbook
13 Translational Medicine and Biomarkers Reading Textbook
14 Case Studies in Drug Discovery Reading Textbook


Contribution of Learning Outcomes to Programme Outcomes
P1 P2 P3 P4 P5 P6 P7 P8 P9 P10 P11 P12
All 4 4 1 2 4 3 3 4 3 3
C1 4 4 1 2 4 2 3 4 3 3
C2 4 4 1 2 4 2 3 4 3 3
C3 3 4 1 2 3 3 3 4 3 3
C4 3 4 1 2 3 3 4 4 3 3

Contribution: 1: Very Slight 2:Slight 3:Moderate 4:Significant 5:Very Significant


https://sis.agu.edu.tr/oibs/bologna/progCourseDetails.aspx?curCourse=71974&lang=en
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