Course Details Language of Instruction English Level of Course Unit Bachelor's Degree Department / Program BIOENGINEERING Type of Program Formal Education Type of Course Unit Elective Course Delivery Method Face To Face Objectives of the Course This course is about the comprehensive view of the stem cell technology with both embryonic and adult stem cells including characteristics at cellular and molecular levels, signaling transduction, stem cell interactions with their microenvironment and their role in regenerative medicine. It covers basic technology involving in stem cell research, stem cell transplantation as a standard treatment for vascular, cardiac and bone disorders. Also, this course emphasizes the potential uses and limitations of stem cells for the treatment of hematological diseases, and ethical issues of stem cell applications in the regenerative medicine. Course Content Course objectives are to: -Defining the current knowledge potential use and development of regenerative medicine. - Describing different types of stem cells and their specific characteristics, and also methods of applications to replace damaged or destroyed cells including tissue engineering. - Explaining the regenerative medicine applications to human diseases. - Evaluating current theories, methods and techniques within the research field and their practical application in the stem cell technology and regenerative medicine. Course Methods and Techniques In this course, student-centered and teacher-centered methods of instructions will be used together. The basic principles of various stem cell techniques will be covered in the lectures. Each student will be asked to present an example of the stem cell techniques and regenerative medicine. The recommended textbooks: The Science of Stem Cells by Jonathan M. W. Slack, Print ISBN:9781119235156 Online ISBN:9781119235293 |DOI:10.1002/9781119235293 © 2018 John Wiley & Sons, Inc. Stem Cells Biology and Application by Mark Clarke, Jonathan Frampton, ISBN 9780815345114, Published July 27, 2020 by Garland Science 462 Pages 456 Color Illustrations. Regenerative Medicine and Stem Cell Biology by Nagwa El-Badri, Springer Nature Switzerland AG 2020, DOI:10.1007/978-3-030-55359-3. Prerequisites and co-requisities None Course Coordinator None Name of Lecturers Asist Prof.Dr. Mesude Bicer mesude.bicer@agu.edu.tr Assistants None Work Placement(s) No Recommended or Required Reading Resources Weekly Schedule: 1 Introduction to stem cell technology and regenerative medicine 2 Embryonic stem cells (ESCs) and human ESCs in regenerative medicine 3 Induced pluripotent stem cells (iPSCs) and their clinical applications 4 Mesenchymal stem cells (MSCs) and their recent therapeutic applications 5 Stem Cell Bioengineering for iPSCs and MSCs 6 Natural, synthetic and composite biomaterials, tissue and organ production via decellularization in 2D and 3D 7 Fall Break 8 Active Learning Week Activity: Group work and Group Discussion 9 Midterm 10 Vascular tissue engineering with stem cell technology and regenerative medicine 11 Cardiac tissue engineering with stem cell technology and regenerative medicine 12 Bone tissue engineering with stem cell technology and regenerative medicine 13 Immunology, immunomodulation and anti-inflammation from stem cells to regenerative medicine introduction 14 Use of large animal models and non-human primate models for regenerative medicine research, Ethical By the end of the course, the student will be able to LO1- Explain scientific principles which underlie stem cell technology and regulation of stem cells and human diseases connected to stem cell biology. LO2- Define various types of stem cells in the human body and the potential uses of stem cells in clinical practices for the regenerative medicine. LO3- Interpret about the clinical, ethical, regulatory aspects of the applications of stem cell therapy and the principles underlying the equipment, reagents, databases and methods commonly used for research in stem cell technology and regenerative medicine. LO4- Advance laboratory techniques that could be used in stem cell research, and also scientific questions in stem cell technology and regenerative medicine. Weekly Schedule: 1 Introduction to stem cell technology and regenerative medicine Activity: Lecture, in class discussion and asynchronous network 2 Embryonic stem cells (ESCs) and human ESCs in regenerative medicine Activity: Lecture, in class discussion and asynchronous network 3 Induced pluripotent stem cells (iPSCs) and their clinical applications Activity: Lecture, in class discussion and asynchronous network 4 Mesenchymal stem cells (MSCs) and their therapeutic applications in the latest advances Activity: Lecture, in class discussion and asynchronous network 5 Stem Cell Bioengineering for iPSCs and MSCs Activity: Lecture, in class discussion and asynchronous network 6 Natural, synthetic and composite biomaterials, tissue and organ fabrication via decellularization in 2D and 3D Activity: Lecture, in class discussion and asynchronous network 7 Fall Break 8 Active Learning Week Activity: Group work and Group Discussion 9 Midterm 10 Vascular tissue engineering with the stem cell technology and regenerative medicine Activity: Lecture, in class discussion and asynchronous network 11 Cardiac tissue engineering with the stem cell technology and regenerative medicine Activity: Lecture, in class discussion and asynchronous network 12 Bone tissue engineering with the stem cell technology and regenerative medicine Activity: Lecture, in class discussion and asynchronous network 13 Introduction to immunology, immunomodulation and anti-inflammation for stem cell to regenerative medicine Activity: Lecture, in class discussion and asynchronous network 14 Use of large animal models and nonhuman primate models for regenerative medicine research, Ethical concerns on stem cell clinical trials Activity: Lecture, in class discussion 15 Student presentations The recommended textbooks: The Science of Stem Cells by Jonathan M. W. Slack, Print ISBN:9781119235156 Online ISBN:9781119235293 |DOI:10.1002/9781119235293 © 2018 John Wiley & Sons, Inc. Stem Cells Biology and Application by Mark Clarke, Jonathan Frampton, ISBN 9780815345114, Published July 27, 2020 by Garland Science 462 Pages 456 Color Illustrations. Regenerative Medicine and Stem Cell Biology by Nagwa El-Badri, Springer Nature Switzerland AG 2020, DOI:10.1007/978-3-030-55359-3. Term Project Report and Term Project Presentation Midterm and Final Course Category Engineering %40 Science %30 Health %30

 





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